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OBJECTIVE:To study the innovation system synergies of pharmaceutical manufacturing industry in Shanghai and lay the foundation for further enhancing the competitiveness of pharmaceutical enterprises of Shanghai. METHODS:Based on the composite system synergy degree model,order variables(G)of innovation environment(S1),innovation technology research and development(S2),innovation technology absorption(S3)and innovation output(S4)in the pharmaceutical manufacturing industry innovation system in Shanghai during 2006-2014 were selected,synergy degree model was built,and order parameter,order de-gree,synergy degree of each order variable were calculated in turn. RESULTS & CONCLUSIONS:S1-S4 obtained 4,4,4,2 or-der variables respectively. According to the calculation,synergy degree of pharmaceutical manufacturing industry in Shanghai dur-ing 2006-2014 ranged in -0.195-0.202,average value was -0.068,overall in the level ofinverse synergyandnon-synergy. Thus,the internal development of the pharmaceutical manufacturing innovation system in Shanghai is more disorderly. It is suggest-ed to reform from the two core influencing factors of the stability of innovative environment and promoting technology absorption, including accelerating the transformation and upgrading of the pharmaceutical industry to create a stable and innovative environ-ment,increasing the innovation investment of the pharmaceutical industry to improve the level of technology absorption and inde-pendent innovation,as well as strengthening cooperation within and outside the domain to effectively enhance the system synergy degree level of pharmaceutical manufacturing innovation system in Shanghai.
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@#ObjectiveTo investigate the effects of Yinhuang solution on the bladder mucosal before and/or after mucosal injury.Methods32 SPF female SD rats were randomly divided into 4 groups with 8 rats in each group. Group A was used for the normal control group, group B for the model control group, group C for preventive group, group D for preventive and therapeutic group. Injured rats were created by hydrochloric acid applied on bladder mucosa. After the models were established or before and after the models were established, bladders were perused with Yinhuang solution. Severity of inflammatory infiltration were observed by HE staining, histological score and heat shock protein 70 (HSP70) expressed in the mucosa.ResultsEndoscopic pathological change showed that group B had a large number of inflammatory cell infiltration, significant expansion of capillary, epithelial cell necrosis. Group C had a small amount of expansion of capillary, inflammatory cell infiltration. Group D scattered in expansion of capillary, a small amount of inflammatory cell infiltration. Concerning the results of histological score and HSP70 expression, there was a significant difference between group A and groups B, C or D (P<0.01); there was a significant difference between group B and groups C or D (P<0.01); there was a significant difference between group C and group D (P<0.05).ConclusionYinhuang solution can evidently improve the repair capability of bladder mucosa after injury.
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Objective To investigate effectiveness of treatment of Upper urinary tract calculus by MPCNL application.Methods From May 2000 to May 2007,causing artificial kidney hydronephrosis for the affected kidney,established renal percutaneous channels(F16～18),which established the single channels of 202 cases,dual-channel of 14 cases,by Ureteroscopic Lithotripsy and holmium laser lithotripsy.Results 183 cases of 216 patients were One-time stone;33 cases were second stone.The average clearance rate is 90.32%,the average operation time is 79min,average valume of about bleeding is 80ml,the average hospitalization days are 8 days,kidney ostomy average stay 7.5 days.Of the operation,9 cases of obviously bleeding(4%)before and after operation,1 case uncontrollable bleeding after interventional treatment failure with Nephrectomy,others to stop beeding by symptomatic treatment,2 cases find urinary extravasation postoperative and cured by adjusting location of renal ostomy.Conclusion Minimally invasive percutaneous nephrolithotomy for the treatment of Upper urinary tract calculus is safe and effective for patients with less trauma,quicker recovery and high learance rate,the efficacy is satifactory.
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Objective To evaluate and compare 3 kinds of cecocolon urinary reservoir. Methods Penn pouch,indiana pouch or detenial cecocolon reservoir has been performed for 37 patients.The out-come was evaluated by urodynamic and clinically. Results Good continence has been achieved in all patients with an appendiceal continence mechanism.The capacity and intrareservoir pressure of detenial cecocolon was significantly different from penn or indiana pouch 3 months postoperatively (P0.05).The intrareservoir pressure on contraction was lower with penn pouch. Conclusions The penn or modified indiana pouch is better and more ideal as an urinary reservoir whereas the detenial cecocolon pouch is technically simpler.